菌株TKU037係篩選自淡水土壤，液態發酵NB (Nutrient Broth) 能生產α-葡萄糖苷酶抑制劑和抗菌物質，經鑑定係屬類芽胞桿菌（Paenibacillus sp.）之一株細菌。本研究探討Paenibacillus sp. TKU037生產α-葡萄糖苷酶抑制劑之較適條件，以及所生產α-葡萄糖苷酶抑制劑之pH值與熱安定性，並且分離出具α-葡萄糖苷酶抑制活性之一化合物1-methylhydantoin。 Bacterial strain TKU037 produced α-glucosidase inhibitors and antibacterial materials when cultured in nutrient broth (NB). Strain TKU037 was isolated from Taiwanese soils and identified as Paenibacillus species. Optimum culture condition for the production of α-glucosidase inhibitors and the pH and thermal stability of the produced inhibitors have been studied. A compound (1-methylhydantoin) with α-glucosidase inhibitor activity has been isolated from the culture supernatant.