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    题名: Screening and evaluation of α-glucosidase inhibitors from indigenous medicinal plants in Dak Lak Province, Vietnam
    作者: Van Bon Nguyen;Quang Vinh Nguyen;Anh Dzung Nguyen;San-Lang Wang
    关键词: α-Glucosidase inhibition;Medicinal plants;Euonymus laxiflorus Champ;Dak Lak
    日期: 201706
    上传时间: 2017-05-25 02:10:12 (UTC+8)
    出版者: Springer
    摘要: α-Glucosidase inhibitors have received much attention due to their important use in treating diabetes mellitus. Although some synthetic α-glucosidase inhibitors have been available for a long time, they often cause various unexpected side effects. Thus, the present study was aimed at finding a safe, natural source of α-glucosidase inhibitors. Twenty-six samples of 22 medicinal plants were collected in the Dak Lak province of Vietnam and evaluated for α-glucosidase inhibitory activity. Trunk bark extract from Euonymus laxiflorus Champ (ELC extract) was selected as the best α-glucosidase inhibitor with the smallest IC50 = 0.36 mg/mL against rat-derived α-glucosidase. This extract had a stronger inhibitory activity against α-glucosidase from Saccharomyces cerevisiae (IC50 = 1.32 µg/mL) and Bacillus stearothermophilus (IC50 = 5.15 µg/mL). The potential inhibition against some other enzymes were tested, and the results showed that the ELC extract did not inhibit fungal cellulase but strongly inhibited porcine α-amylase (IC50 = 6.7 µg/mL). The ELC extract also inhibited the proteases papain and bromelain, with IC50 = 339 µg/mL and IC50 = 226 µg/mL, respectively. The thermal and pH stabilities of the ELC extract were also investigated.
    關聯: Research on Chemical Intermediates 43(6),p.3599-3612
    DOI: 10.1007/s11164-016-2434-x
    显示于类别:[化學學系暨研究所] 期刊論文


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