English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 62797/95867 (66%)
造訪人次 : 3732396      線上人數 : 326
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/109483


    題名: Antioxidant and cytotoxic activity of lichens collected from Bidoup Nui Ba National Park, Vietnam
    作者: Nguyen TTH;Dinh MH;Wang SL;Nguyen QV;Tran TD;Nguyen AD
    關鍵詞: Lichen;Methanol extracts;Cytotoxicity;MCF-7;MO-91;Fibroblast Peripheral blood mononuclear cells
    日期: 2019
    上傳時間: 2017-02-21 02:11:24 (UTC+8)
    出版者: Springer Netherlands
    摘要: Lichens were some of the earliest colonizers of terrestrial habitats on Earth. They represent a unique symbiont between fungi (mycobionts) and algae and/or cyanobacteria (photobionts). Lichens have been used as a cure for diabetes, coughs, pulmonary tuberculosis, wound healing, and dermatological diseases. The aim of this study is to investigate the in vitro antioxidant and cytotoxic activities of methanol lichen extracts. Fourteen lichen species from Bidoup Nui Ba National Park were identified according to their morphology and anatomical and chemical characteristics. The antioxidant activity of the methanol lichen extracts was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. The results showed that, of the lichens tested, L5 had the highest free radical activity with 50% inhibitory concentration (IC50) of 59.9 ± 4.65 mg mL−1. The methanol extract of L5 also showed the highest total flavonoid and polyphenol contents. In a cytotoxic assay, it was observed that the methanol extract of U38.1 exhibited high cytotoxic effect against MCF-7 cells, with IC50 of 34.27 ± 1.25 mg mL−1. The tested lichen extracts were also found to have slight cytotoxic effect on fibroblasts at screening concentration of 100 µg mL−1. All of the extracts were found to possess different cytotoxic activities against MO-91 cells, with IC50 values ranging from 10.50 ± 1.56 to over 50 mg mL−1. All of the extracts except U38.1 induced normal peripheral blood mononuclear cell (PBMC) proliferation, especially after 48 h of treatment at 25 µg/mL.
    關聯: Research on Chemical Intermediates 45(1), p.33-49
    DOI: 10.1007/s11164-018-3628-1
    顯示於類別:[化學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    201706 RCI nanoparticle.pdf1195KbAdobe PDF495檢視/開啟
    index.html0KbHTML63檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋