English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 57610/91130 (63%)
造訪人次 : 13524234      線上人數 : 288
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/109482

    題名: Free radical scavenging and antidiabetic activities of Euonymus laxiflorus Champ. extract
    作者: Nguyen QV;Nguyen NH;Wang SL;Nguyen VB;Nguyen AD
    關鍵詞: Antidiabetic activity;α-Glucose;α-amylase inhibition;Euonymus laxiflorus Champ.;DPPH radical scavenging
    日期: 2017-10
    上傳時間: 2017-02-21 02:11:22 (UTC+8)
    出版者: Springer Netherlands
    摘要: In recent years, due to the undesirable side-effects of synthetic drugs used to treat diabetes, research into herbal medicines for treatment of this disease has increased. Euonymus laxiflorus Champ. belongs to the Celastraceae family, long used in traditional Vietnamese medicine by ethnic people living in Dak Lak Province of Vietnam. The aim of this study is to evaluate the antioxidant and antidiabetic activities of methanol extract of Euonymus laxiflorus Champ. trunk bark. The antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, and the antidiabetic activity was determined by inhibition of digestive enzymes and lowering of fasting blood glucose in diabetic rats. The contents of flavonoids and polyphenols were also determined spectroscopically. The results indicated that trunk bark extract of Euonymus laxiflorus Champ. possessed relatively high antioxidant activity with 50% inhibition concentration (IC50) of 0.60 mg/ml, compared with 0.24 mg/ml for l-ascorbic acid as positive control. Furthermore, the extract also exhibited relatively higher α-glucosidase inhibitory and moderately lower α-amylase inhibitory effects compared with acarbose. Moreover, the extract could lower fasting blood glucose levels in rats with streptozotocin-induced diabetes but without inducing body weight loss, compared with acarbose. However, the extract did not produce any hypoglycemic effect in normal rats at dose up to 300 mg/kg body weight. These results suggest that methanol extract of Euonymus laxiflorus Champ. may prove to be useful in treating type 2 diabetes.
    關聯: Research on Chemical Intermediates 43(10), p.5615-5624
    DOI: 10.1007/s11164-017-2951-2
    顯示於類別:[化學學系暨研究所] 期刊論文


    檔案 描述 大小格式瀏覽次數
    Free radical scavenging and antidiabetic.pdf526KbAdobe PDF0檢視/開啟



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋