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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/109464


    Title: The Effect of the First Spontaneous Bacterial Peritonitis Event on the Mortality of Cirrhotic Patients with Ascites: A Nationwide Population-Based Study in Taiwan
    Authors: Hung, Tsung-Hsing;Tsai, Chen-Chi;Hsieh, Yu-Hsi;Tsai, Chih-Chun;Tseng, Chih-Wei;Tseng, Kuo-Chih
    Keywords: Cirrhosis;Spontaneous bacterial peritonitis;Ascites;Mortality
    Date: 2016-09-15
    Issue Date: 2017-02-21 02:10:33 (UTC+8)
    Publisher: Gut and Liver, Editorial Office
    Abstract: Background/Aims
    Spontaneous bacterial peritonitis (SBP) contributes to poorer short-term mortality in cirrhotic patients with ascites. However, it is unknown how long the effect of the first SBP event persists in these patients.

    Methods
    The National Health Insurance Database, derived from the Taiwan National Health Insurance Program, was used to identify and enroll 7,892 cirrhotic patients with ascites who were hospitalized between January 1 and December 31, 2007. All patients were free from episodes of SBP from 1996 to 2006.

    Results
    The study included 1,176 patients with SBP. The overall 30-day, 90-day, 1-year, and 3-year mortality rates in this group were 21.8%, 38.9%, 57.5%, and 73.4%, respectively. The overall 30-day, 90-day, 1-year, and 3-year mortality rates in the non-SBP group were 15.7%, 32.5%, 53.3%, and 72.5%, respectively. After adjusting for gender, age, and other medical comorbidities, the adjusted hazard ratios of SBP for 30-day, 30- to 90-day, 90-day to 1-year, and 1- to 3-year mortality were 1.49 (95% confidence interval [CI], 1.30 to 1.71), 1.19 (95% CI, 1.02 to 1.38), 1.04 (95% CI, 0.90 to 1.20), and 0.90 (95% CI, 0.77 to 1.05), respectively, compared with the non-SBP group.

    Conclusions
    The effect of SBP on the mortality of cirrhotic patients with ascites disappeared in those surviving more than 90 days after the first SBP event.
    Relation: Gut and Liver 10(5), pp.803–807
    DOI: 10.5009/gnl13468
    Appears in Collections:[數學學系暨研究所] 期刊論文

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