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    Title: No Difference in Mortality between Terlipressin and Somatostatin Treatments in Cirrhotic Patients with Esophageal Variceal Bleeding and Renal Functional Impairment
    Authors: Hung, Tsung-Hsing;Tsai, Chen-Chi;Tseng, Chih-Wei;Tseng, Kuo-Chih;Hsieh, Yu-Hsi;Tsai, Chih-Chun
    Keywords: esophageal variceal bleeding;renal function impairment;somatostatin;terlipressin
    Date: 2016-11-01
    Issue Date: 2017-02-21 02:10:31 (UTC+8)
    Abstract: Objective
    To study the differences in mortality between terlipressin and somatostatin treatments in cirrhotic patients with esophageal variceal bleeding (EVB) and renal functional impairment (RFI).

    Methods
    The National Health Insurance Database, part of the Taiwan National Health Insurance Program, was used to enroll cirrhotic patients who had received endoscopic variceal ligation plus somatostatin or terlipressin for EVB and who were hospitalized between 1 January 2007 and 31 December 2010. The differences in mortality between the two vasoactive agents were compared and the risk factors for 30-day mortality because of EVB were identified.

    Results
    A total of 2324 cirrhotic patients with EVB were enrolled. The 30-day mortality data showed no significant differences between the somatostatin and the terlipressin groups (P=0.232). The risk of 30-day mortality was significantly higher in male patients [hazard ratio (HR): 1.50, P=0.002] and patients with hepatic encephalopathy (HR: 1.82, P<0.001), ascites (HR: 1.32, P=0.008), bacterial infections (HR: 2.10, P<0.001), hepatocellular carcinoma (HR: 2.09, P<0.001), and RFI (HR: 3.89, P<0.001). A subgroup analysis of cirrhotic patients with RFI was carried out. The overall 30-day mortality was higher in patients treated with somatostatin than in those treated with terlipressin (52.6 vs. 42.3%), but the difference failed to reach significance (adjust HR: 1.49, 95% confidence interval: 0.94–2.37, P=0.091).

    Conclusion
    RFI was the most important risk factor for 30-day mortality in EVB patients. Terlipressin and somatostatin had similar effects on 30-day mortality in cirrhotic patients with EVB and RFI.
    Relation: European Journal of Gastroenterology & Hepatology 28(11), pp.1275–1279
    DOI: 10.1097/MEG.0000000000000703
    Appears in Collections:[數學學系暨研究所] 期刊論文

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