The Effect of Renal Function Impairment on the Mortality of Cirrhotic Patients: A Nationwide Population-Based 3-Year Follow-up Study

doi:10.1371/journal.pone.0162987

機構典藏 > College of Sciences > Department of Applied Mathematics and Data Science > Journal Article > Item 987654321/109462

Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/109462

Title:	The Effect of Renal Function Impairment on the Mortality of Cirrhotic Patients: A Nationwide Population-Based 3-Year Follow-up Study
Authors:	Hung, Tsung-Hsing;Lay,Chorng-Jang;Tseng, Chih-Wei;Tsai, Chih-Chun;Tsai, Chen-Chi
Date:	2016-09-15
Issue Date:	2017-02-21 02:10:29 (UTC+8)
Publisher:	Public Library of Science
Abstract:	Renal function impairment (RFI) contributes to poor prognosis in cirrhotic patients. However, there have been no studies that seek to identify the effect of different types of RFI on the mortality of cirrhotic patients. We used the National Health Insurance Database, derived from the Taiwan National Health Insurance Program, to identify 44365 cirrhotic patients between January 1, 2007 and December 31, 2007. RFI was identified in 2832 cirrhotic patients, including 1075 with acute renal failure (ARF) (169 with hepatorenal syndrome, HRS; 906 with non-hepatorenal syndrome, NHRS), 705 with chronic kidney disease (CKD), and 1052 with end stage renal disease (ESRD). After Cox proportional hazard regression analysis adjusted by gender, age, and comorbid disorders, the 30-day, 30 to 90-day, 90-day to 1-year, and 1 to 3-year mortality hazard ratios (HR) compared to the non-RFI group were: (ARF) 5.19 (4.70–5.74), 3.23 (2.76–3.77), 1.51 (1.26–1.81), and 1.35 (1.13–1.61), respectively; (CKD) 2.70 (2.30–3.18), 2.03 (1.66–2.49), 1.60 (1.34–1.90), and 1.26 (1.06–1.49), respectively; and (ESRD) 1.42 (1.17–1.72), 1.62 (1.35–1.94), 1.90 (1.68–2.15), and 1.67 (1.48–1.89), respectively. Compared to NHRS, the 30-day, 30 to 90-day, 90-day to 1-year, and 1 to 3-year mortality HRs of HRS were 1.03 (0.80–1.32), 2.13 (1.46–3.11), 1.58 (0.90–2.75), and 2.51 (1.41–4.48), respectively, in cirrhotic patients with ARF. These results indicate the effects of CKD and ESRD on the mortality of cirrhotic patients are distributed equally in every survival stage, whereas the effect of ARF appears only in the early stage. Compared to NHRS, HRS contributes to a higher mortality risk at the late survival stage.
Relation:	PLoS One 11(9), p.e0162987
DOI:	10.1371/journal.pone.0162987
Appears in Collections:	[Department of Applied Mathematics and Data Science] Journal Article

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	227	View/Open
The Effect of Renal Function Impairment on the Mortality of Cirrhotic Patients A Nationwide Population-Based 3-Year Follow-up Study.PDF		1213Kb	Adobe PDF	0	View/Open

Loading...