Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

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Title:	Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma
Authors:	Yen-Ta Lu;Tien-Ling Chen;Kuo-Song Chang;Chia-Ming Chang;Tsai-Yin Wei;Jen-Wei Liu;Chih-Ang Hsiao;Tzenge-Lien Shih
Keywords:	Benzazole;B16F10 cells;Melanoma;MTS assay;Naphthalimide;Topoisomerase II
Date:	2017-01-15
Issue Date:	2016-12-27 02:10:23 (UTC+8)
Publisher:	Pergamon Press
Abstract:	Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.
Relation:	Bioorganic Medicinal Chemistry 25(2), p.789-794
DOI:	10.1016/j.bmc.2016.11.057
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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