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    題名: Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma
    作者: Yen-Ta Lu;Tien-Ling Chen;Kuo-Song Chang;Chia-Ming Chang;Tsai-Yin Wei;Jen-Wei Liu;Chih-Ang Hsiao;Tzenge-Lien Shih
    關鍵詞: Benzazole;B16F10 cells;Melanoma;MTS assay;Naphthalimide;Topoisomerase II
    日期: 2017-01-15
    上傳時間: 2016-12-27 02:10:23 (UTC+8)
    出版者: Pergamon Press
    摘要: Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.
    關聯: Bioorganic Medicinal Chemistry 25(2), p.789-794
    DOI: 10.1016/j.bmc.2016.11.057
    顯示於類別:[化學學系暨研究所] 期刊論文

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