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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/109027


    Title: Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma
    Authors: Yen-Ta Lu;Tien-Ling Chen;Kuo-Song Chang;Chia-Ming Chang;Tsai-Yin Wei;Jen-Wei Liu;Chih-Ang Hsiao;Tzenge-Lien Shih
    Keywords: Benzazole;B16F10 cells;Melanoma;MTS assay;Naphthalimide;Topoisomerase II
    Date: 2017-01-15
    Issue Date: 2016-12-27 02:10:23 (UTC+8)
    Publisher: Pergamon Press
    Abstract: Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.
    Relation: Bioorganic Medicinal Chemistry 25(2), p.789-794
    DOI: 10.1016/j.bmc.2016.11.057
    Appears in Collections:[化學學系暨研究所] 期刊論文

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