淡江大學機構典藏:Item 987654321/108852
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 62805/95882 (66%)
造訪人次 : 3942184      線上人數 : 1041
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/108852


    題名: Abnormal Perfusion in Patellofemoral Subchondral Bone Marrow in the Rat Anterior Cruciate Ligament Transection Model of Post-traumatic Osteoarthritis: a Dynamic Contrast-enhanced Magnetic Resonance Imaging Study
    作者: Tsai, Ping-Huei;Lee, Herng-Sheng;Siow, Tiing Yee;Wang, Chao-Ying;Chang, Yue-Cune;Lin, Ming-Huang;Hsu, Yi-Chih;Lee, Chian-Her;Chung, Hsiao-Wen;Huang, Guo-Shu
    關鍵詞: Post-traumatic osteoarthritis;Patellofemoral joint;Anterior cruciate ligament;DCE-MRI;Perfusion;Subchondral bone marrow
    日期: 2016-01-01
    上傳時間: 2016-12-17 02:10:34 (UTC+8)
    摘要: Objective

    Although anterior cruciate ligament (ACL) injury is a well-recognized risk factor for developing knee post-traumatic osteoarthritis (PTOA), the process in the patellofemoral (PF) joint after ACL injury is still under-researched. Our aim was to investigate the perfusion changes in PF subchondral bone marrow in the rat ACL transection (ACLX) model of PTOA using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

    Design

    Eighteen male Sprague Dawley rats were randomly separated into three groups (n = 6 each group): a normal control group and groups receiving ACLX and sham-surgery, respectively, in the right knee. Perfusion parameters in the patellar and femoral subchondral bone marrows of all rats were measured on DCE-MRI at 0, 4, 8, and 16 weeks after respective treatment. After the last MRI at week 16, the rats were sacrificed and their right knees were harvested for histologic examination. In addition, to observe the long-term histologic change in PF joints, 9 additional rats (n = 3 in each group) were included and sacrificed at week 32 for histologic examination.

    Results

    In the ACLX group vs the sham and control groups, the perfusion parameters were significantly changed in both patellar and femoral subchondral bone marrows at week 16. Histologic examination revealed cartilage defects in ACLX rats at 32 weeks after surgery.

    Conclusions

    These data point to a possible functional relationship between subchondral bone marrow perfusion abnormalities and cartilage breakdown in PTOA. Moreover, the perfusion parameters derived from DCE-MRI can potentially serve as biomarkers of early OA.
    關聯: Osteoarthritis and Cartilage 24(1), pp.129-133
    DOI: 10.1016/j.joca.2015.07.015
    顯示於類別:[數學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    null0KbUnknown38檢視/開啟
    index.html0KbHTML213檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋