淡江大學機構典藏:Item 987654321/107552
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 62793/95819 (66%)
造访人次 : 3638384      在线人数 : 313
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/107552


    题名: 利用環境敏感性嵌段共聚物與幾丁聚醣自組裝形成複合顆粒
    其它题名: Preparation of controlled drug-release carriers by self-assembly of environmentally sensitive block copolymer and chitosan
    作者: 林莉婕;董崇民
    关键词: 溫度敏感型;酸鹼敏感型;可逆加成-斷裂鏈轉移聚合;幾丁聚醣;葉酸;藥物釋放系統;thermal-responsive;pH-responsive;reversible addition-fragmentation chain transfer polymerization;chitosan;folic acid;drug delivery system
    日期: 2016-06-24
    上传时间: 2016-09-23 02:10:44 (UTC+8)
    摘要: 本研究主要在製備具溫度及pH值雙重敏感性且具葉酸標靶的奈米複合載體以作為藥物控制釋放載體,利用腫瘤細胞上具有葉酸受體及腫瘤附近的pH值較低,希望藉由葉酸標靶的特性,使藥物載體在腫瘤細胞附近時,藥物載體表面上的葉酸與受體結合,再根據其酸鹼敏感的特性進行藥物釋放。此研究是利用丙烯酸(Acrylic acid, AA)與氮-異丙基丙烯醯胺(N-isopropylamide,NIPAAm)以可逆加成-斷裂鏈轉移聚合(Reversible addition-fragmentation chain transfer polymerization,RAFT)活性自由基聚合方法合成末端帶有酸基和十二烷基三硫代碳酸酯的窄分子量分佈PAA-b-PNIPAAm共聚物,作為環境敏感型高分子主體,並藉由調整高分子的pH值來控制低臨界溫度值(Lower critical solution temperature,LCST),當pH值調整至6及7時,可以得到LCST接近於人體溫度37 oC,隨後透過動態光散射及TEM證明高分子具自組裝的能力。接著利用EDC/NHS活化葉酸上的酸基將其接枝至幾丁聚醣上,以紫外光-可見光分光光度計計算葉酸的接枝比,Chitosan-folate的葉酸接枝比為1.52%。最後,將PAA-b-PNIPAAm溶液加入葉酸修飾幾丁聚醣溶液中進行反應形成Chitosan-folate/PAA-b-PNIPAAm複合載體,以動態光散射探討其微胞型態。
    In this study﹐dual thermo- and pH-responsive and folate-target nanocomposites were prepared to serve as potential carriers for controlled delivery of drugs. Reversible addition-fragmentation chain transfer (RAFT) polymerization of acrylic acid (AA) and N-isopropylamide (NIPAAm) was used to synthesize PAA-b-PNIPAAm copolymers with acid and dodecyltrithiocarbonate end groups. The PAA-b-PNIPAAm copolymers were environment-responsive and had narrow molecular weight distribution. Adjusting the pH to 6 and 7 could bring the lower critical solution temperature (LCST) of the copolymers to around average normal body temperature (37 oC). Self-assembling properties of the copolymers were observed by dynamics light scattering (DLS) and transmission electron microscopy (TEM). Chitosan was modified with folic acid in HAc(aq)/DMSO through the reaction of amino group with carboxyl group. The degree of folic acid substitution was calculated to be 1.52%. At last, the Chitosan-folate/PAA-b-PNIPAAm composite carriers were prepared by adding the PAA-b-PNIPAAm solution into Chitosan-folate solution. DLS were used to investigate the micelle morphology of the Chitosan-folate/PAA-b-PNIPAAm composite carriers.
    關聯: 2016年幾丁質幾丁聚醣暨生醫材料研討會
    显示于类别:[化學工程與材料工程學系暨研究所] 會議論文

    文件中的档案:

    没有与此文件相关的档案.

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈