Radiofrequency ablation (RFA) is a technique by which deposition of electromagnetic energy is used to thermally heat tissues. And, incomplete treatment with heat-based therapy alone may sometimes occur. To improve the efficacy of thermal therapies, many attempts have been used by modifying the tumor’s underlying physiologic characteristics. The objective of this study is to determine whether fluid saline injection during radiofrequency ablation (RFA) can increase the coagulation area. As well as the parameters of both electrical conductivity and blood perfusion would have impact on thermal lesion formation.