Preparation of asymmetric polyhydroxybutyrate/chitosan composite membrane for guided bone regeneration

淡江大學機構典藏 > 工學院 > 化學工程與材料工程學系暨研究所 > 會議論文 > Item 987654321/107423

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/107423

题名:	Preparation of asymmetric polyhydroxybutyrate/chitosan composite membrane for guided bone regeneration
作者:	Don, Trong-Ming;Tai, Hung-Yin;Cheng, Liao-Ping;Lien, Wei
日期:	2013-11-17
上传时间:	2016-08-18 13:40:31 (UTC+8)
摘要:	In this study, an asymmetric composite membrane composed of a porous chitosan layer and a dense polyhydroxybutyrate (PHB) layer was prepared, and its mechanical properties as well as cellular compatibility were evaluated. First, the PHB dense layer with a thickness of ca. 32 m was obtained by direct oven-drying. After being treated with plasma to produce free radicals on the surface and subsequently graft polymerized with poly(acrylic acid), the PHB was immersed in the CS solution where the CS chains could be chemically bonded to the PHB surface via carbodiimide activation. After lyophilization, an asymmetric PHB/CS composite membrane was obtained. Compared to the porous CS membrane, the composite membrane had higher tensile mechanical properties. In addition, the fibroblast cells (L929 and HGF) and human osteoblast cells (hFOB1.19) were cultured on both sides of the composite membrane. All the cells could proliferate very well indicating that both PHB and CS layers were cellular compatible. Yet, the PHB dense layer could prohibit the fibroblast cells to penetrate through the membrane. Thus, the asymmetric composite membrane can be use as a potential barrier membrane for guided bone regeneration in periodontal tissue engineering.
關聯:	The 13th Pacific Polymer Conference Program book, Poster-S8-034, pp.107
显示于类别:	[化學工程與材料工程學系暨研究所] 會議論文

文件中的档案:

没有与此文件相关的档案.

在機構典藏中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....