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    题名: Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
    作者: Yan, De-Yue;Ni, Lin-Kai;Chen, Ho-Lun;Chen, Li-Chou;Chen, Yau-Hung;Cheng, Chien-Chung
    关键词: Liposome;Resveratrol;Norcantharidin;Drug delivery;Tadpole structure
    日期: 2016-02-01
    上传时间: 2016-08-15
    出版者: Pergamon Press
    摘要: Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol–norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
    關聯: Bioorganic & Medicinal Chemistry Letters 26(3), pp.774-777
    DOI: 10.1016/j.bmcl.2015.12.099
    显示于类别:[化學學系暨研究所] 期刊論文

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