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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/107113

    Title: Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
    Authors: Yan, De-Yue;Ni, Lin-Kai;Chen, Ho-Lun;Chen, Li-Chou;Chen, Yau-Hung;Cheng, Chien-Chung
    Keywords: Liposome;Resveratrol;Norcantharidin;Drug delivery;Tadpole structure
    Date: 2016-02-01
    Issue Date: 2016-08-15
    Publisher: Pergamon Press
    Abstract: Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol–norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
    Relation: Bioorganic & Medicinal Chemistry Letters 26(3), pp.774-777
    DOI: 10.1016/j.bmcl.2015.12.099
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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