English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 54388/89187 (61%)
造访人次 : 10568531      在线人数 : 17
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻

    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/107113

    题名: Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
    作者: Yan, De-Yue;Ni, Lin-Kai;Chen, Ho-Lun;Chen, Li-Chou;Chen, Yau-Hung;Cheng, Chien-Chung
    关键词: Liposome;Resveratrol;Norcantharidin;Drug delivery;Tadpole structure
    日期: 2016-02-01
    上传时间: 2016-08-15
    出版者: Pergamon Press
    摘要: Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol–norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
    關聯: Bioorganic & Medicinal Chemistry Letters 26(3), pp.774-777
    DOI: 10.1016/j.bmcl.2015.12.099
    显示于类别:[化學學系暨研究所] 期刊論文


    档案 描述 大小格式浏览次数



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈