English  |  正體中文  |  简体中文  |  Items with full text/Total items : 56828/90533 (63%)
Visitors : 12259143      Online Users : 168
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/107113


    Title: Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
    Authors: Yan, De-Yue;Ni, Lin-Kai;Chen, Ho-Lun;Chen, Li-Chou;Chen, Yau-Hung;Cheng, Chien-Chung
    Keywords: Liposome;Resveratrol;Norcantharidin;Drug delivery;Tadpole structure
    Date: 2016-02-01
    Issue Date: 2016-08-15
    Publisher: Pergamon Press
    Abstract: Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol–norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
    Relation: Bioorganic & Medicinal Chemistry Letters 26(3), pp.774-777
    DOI: 10.1016/j.bmcl.2015.12.099
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML136View/Open
    index.html0KbHTML69View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback