The authors argue that how to screen mutual funds to derive satisfactory returns would be a worthwhile topic for investigation, since investors seem unsatisfied with their returns on mutual fund investments as their expectations. However, the screening approaches related to mutual funds seem rarely explored in the relevant studies. We then explore whether employing three screening approaches employed in Taiwan would enhance the profitability of mutual fund investments. This study also takes the lump sum (LS) and dollar-cost average (DCA) investments as well as the take-profit and stop-loss mechanism into account due to the concern of investors’ behaviors. The results reveal that these screening approaches would matter for Taiwan mutual fund investments, LS investments yield better results than DCA investments, and mutual fund investments without take-profit and stop-loss outperform those with take-profit and stop-loss. These findings indicate that these screening approaches, LS and DCA, and take-profit and stop-loss mechanism would matter for mutual fund investments.