Reinvestigation the synthesis of quinolones from ortho-amidoacetophenones by trimethylsilyl trifluoromethanesulfonate
(TMSOTf) mediated reaction is reported. In addition to receiving the expected
quinolones, an unexpected intermolecular self-condensation adduct was also isolated. The detailed
mechanism of its formation is discussed.
Reinvestigation of ortho-amidoacetophenones' cyclization mediated by trimethylsilyl trifluoromethanesulfonate. The Lewis-acid-assisted and Brønsted-acid-catalyzed reaction.pdf
