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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/105262

    Title: 含硼衍生物之合成與其在硼中子捕獲治療之應用
    Other Titles: Synthesis of boron-containing derivatives as the boron-neutron therapy agent
    Authors: 吳孟儒;Wu, Meng-Ju
    Contributors: 淡江大學化學學系碩士班
    潘伯申;Pan, Po-Shen
    Keywords: ;Ugi-4CR;硼中子捕獲治療;boron;Ugi-4CR;BNCT
    Date: 2015
    Issue Date: 2016-01-22 14:51:47 (UTC+8)
    Abstract: Ugi反應合成多重含硼化合物(I)
    利用Miyaura Borylation reaction進行反應(II)
    本研究利用Miyaura reaction進行硼化反應的合成策略來建構如之含硼化合物,希望在藥物開發上能讓藥物的結構有更多的變化將會是一大突破,在實驗上我們也成功的合成出含硼酯官能基的化合物,但在粗產物的純化,並不容易,使得此策略在執行上較為困難。
    1. Synthesis of Tris-boron-containing Derivatives via Ugi Reaction
    In this project, we used the Ugi-4CR as a platform to synthesize 12 tri-boron-containing di-peptides compounds. These compounds are new and could be biologically interesting. Zebrafish screening is currently employed to investigate the toxicological profile of these molecules and the results will be reported in due course.
    2. Use Miyaura Borylation reaction (II)
    In this project, the Miyaura Borylation reaction was utilized to intall the boron functionality onto the bromo-dipeptide derivatives. One successful example was presented in this section.
    3. The use of boron-containing isocyanides in the Ugi reaction
    In this project, we’ve discovered a N-formylation agent called N-formylsaccharin suitable for the synthesis of boron-containing formamide. The synthesized boron-containing formamide be further dehydrated by POCl3 to form the corresponding boron-containing isocyanides. Furthermore, we used these boron-containing isocyanides as one of the key building blocks in Ugi-4CR reaction to obtain 7 tetra-boron-containing compounds. These compounds could be potentially utilized in boron neutron capture therapy due to their high boron content. The biological evaluation using zebrafish model will be reported in due course.
    Appears in Collections:[化學學系暨研究所] 學位論文

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