含硼異腈化合物之合成及其在多組成反應上的應用

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Title:	含硼異腈化合物之合成及其在多組成反應上的應用
Other Titles:	Synthesis of boron-containing isocyanides and their use in isocyanide-based multicomponent reactions
Authors:	傅嘉杰;Fu, Chia-Chieh
Contributors:	淡江大學化學學系碩士班潘伯申;Pan, Po-Shen
Keywords:	含硼異腈;多組成反應;Boron-containing;Ugi reaction;isocyanide
Date:	2015
Issue Date:	2016-01-22 14:51:45 (UTC+8)
Abstract:	Ugi反應合成多重含硼硼化合物(I) 本論文共包含兩個研究主題，本實驗設計與合成出一系列的Ugi-4CR反應，以微波加熱之合成及純化方法，成功的合成出一系列含三個硼原子化合物。含硼異腈化合物及其應用Ugi反應(II) 根據上述所合成出的含三個硼原子化合物，為了提高單分子含硼量，因此本實驗將合成含硼異腈化合物，成功合成一系列含硼異腈化合物。利用此含硼異腈化合物進行Ugi-4CR反應，且成功合成一系列含單硼和四個硼原子化合物。 In the first project, we have developed an efficient synthesis of tris- boron-containing dipeptide derivatives using the Ugi-4CR . These compounds could be purified via acid/base extraction protocol, which provided an easy access to the boron compound libraries . In the second project, I have optimized the condition for the synthesis of boron-containing isocyanides Unlike the existing strategies, the described synthetic strategy offers the desire compounds with the reduced reaction time along with the simple purification protocol. . These boron-containing isocyanides were further utilized in Ugi-4CR to yield tetra-boron-containing dipeptide derivatives , in which could be used in boron neutron capture therapy .
Appears in Collections:	[Graduate Institute & Department of Chemistry] Thesis

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