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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/105258

    Title: 含硼胜肽化合物之合成(I);利用Passerini反應合成多重含硼化合物(II)
    Other Titles: Synthesis of boron-containing peptide analogs (I);Synthesis of multiple boron-containing analogs via passerini reaction (II)
    Authors: 劉品毅;Liu, Pin-Yi
    Contributors: 淡江大學化學學系碩士班
    Keywords: ;passerini反應;多組成反應;硼中子捕獲治療;boron;Passerini reaction;Mutilcomponent reaction;BNCT
    Date: 2015
    Issue Date: 2016-01-22 14:51:41 (UTC+8)
    Abstract: 含硼胜肽化合物之合成(I):
    利用Passerini反應合成多重含硼化合物(II) :
    本研究目的在於開發適用於硼中子捕獲治療的藥物,鑒於硼中子捕獲治療的重要性並結合Passerini reaction的廣泛應用性,利用含硼官能基合成出一系列用在硼中子捕獲治療的多重含硼之Passerini化合物,期望能對癌症治療有進一步的發展。未來將以所得之化合物進行一系列的藥物化學結構與活性關係的分析,找出作為後續藥物開發的領導藥物。
    Synthesis of Boron-containing peptide Analogs(I):
    In this research, we have designd and synthesized two series of boron-containing analogues. These compounds could be easily synthesized and purified via simple synthetic operations.More analogs are being synthesized and the result will be reported in due course.

    Synthesis of Multiple Boron-containing Analogs via Passerini Reaction(II):
    In this report, a Passerini three-component reaction with a boron- containing starting material in water under microwave irradiation was developed.We developed these compounds suitable for BNCT drugs.
    Appears in Collections:[化學學系暨研究所] 學位論文

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