本研究旨在探討罕見疾病照顧者相依關係、心理彈性與心理健康之間的關係，以206位罕見疾病照顧者為研究對象，採用問卷調查法進行資料蒐集，使用的研究工具包括相依關係量表(Mutuality Scale)、心理彈性量表(AAQ-II)以及華人健康問卷(CHQ-12)，所得資料以描述性統計、Pearson 積差相關，以及多元迴歸等統計方法進行分析。 本研究發現如下： 1. 206位照顧者中，有55位照顧者在心理健康上的得分低於切截分數，顯示有四分之一的照顧者因長期的照顧任務在心理健康狀態上受到影響。 2. 照顧者相依關係、心理彈性與心理健康之相關分析： (1)照顧者的「心理彈性」與「相依關係」有顯著正相關，表示照顧者心理彈性越好， 相依關係越佳。 (2)照顧者的「相依關係」與「心理健康」有顯著正相關，表示照顧者相依關係越好， 心理健康越佳。 (3)照顧者的「心理彈性」與「心理健康」有顯著正相關，表示照顧者心理彈性越好， 心理健康越佳。 3. 照顧者的心理彈性與相依關係可共同解釋其心理健康30.5%的變異量，且心理彈性對相依關係與心理健康的關係具有部分中介效果。 最後，研究者根據本研究結果加以討論，並提出具體建議，以供相關實務工作者及未來的研究者作為參考。 The study aims to explore mutuality, psychological flexibility, and mental health among cargivers of family memebers with rare diseases. The participants were 206 family caregivers. The data was collected and conducted through questionnaire survey. The instruments adopted by the researcher in the study consisted of the Mutuality Scale, acceptance and actionquestionnaire-II (AAQ-II) and the Chinese Health Questionnaire (CHQ-12). The researcher applied the Statistical Package for Social Science 20.0 (SPSS 20.0) for Mac to deal with the collected data, including descriptive statistics, Pearson’s Correlation, and Regression Analysis. The following are the findings of this study: 1. Research shows that 55 out of 206 caregivers who care for patients with rare diseases have lower mental health scores than cutoff score. This shows that almost a quarter of the caregivers who look after family members with rare diseases often suffer from mental health problems. 2. The result of Pearson’s Correlation among mutuality, psychological flexibility and mental health: (1) Psychological flexibility was found to associate positively with mutuality. When the caregivers have higher psychological flexibility, the caregivers have better mutuality. (2) Psychological flexibility was found to associate positively with mental health.When the caregivers have higher psychological flexibility, the caregivers have better mental health. (3) Mutuality was found to associate positively with mental health.When the caregivers’ have higher mutuality, the caregivers have better mental health. 3. Psychological flexibility and mutuality accounted for 30.5% of the variance of mental health, and psychological flexibility partially mediated the association between mutuality and mental health. The researchers, using the results of this study, discussed and proposed concrete suggestions for those who do relevant practical jobs and/or further research in the future.