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    題名: Association between Zolpidem Use and Glaucoma Risk: A Taiwan Population-Based Case-control Study
    作者: Ho, Yi-Ha;Chang, Yue-Cun;Huang, Wei-Chen;Chen, Hsin-Yi;Lin, Che-Chen;Sung, Fung-Chang
    關鍵詞: zolpidem;glaucoma;Taiwanese
    日期: 2015-01-05
    上傳時間: 2016-01-06 11:26:54 (UTC+8)
    出版者: Japan Epidemiological Association
    摘要: Background: To date, the relationship between zolpidem use and subsequent risk of glaucoma in a Taiwanese population has not been assessed.
    Methods: We used data from the National Health Insurance system to investigate whether zolpidem use was related to glaucoma risk. A 1:4 matched case-control study was conducted. The cases were patients newly diagnosed with glaucoma from 2001 to 2010. The controls were randomly selected non-glaucoma subjects matched by sex and age (±5 years). Zolpidem exposure and/or the average dosage of zolpidem used (mg/year) were evaluated. Medical comorbidities were considered as confounding factors. Multiple logistic regression models were used to evaluate the potential risk of zolpidem exposure on glaucoma with/without adjustment for the effects of confounding variables.
    Results: The exposure rate of zolpidem use in the glaucoma group was significantly higher than that of the control group (2.8% vs. 2.0%, P < 0.0001). The adjusted odds ratio (OR) of the risk of glaucoma for those with zolpidem use vs. those without was 1.19 (95% confidence interval [CI], 1.02-1.38). Compared to non-zolpidem users, zolpidem users with an average dose of more than 200 mg/year had significantly increased risk of glaucoma (OR 1.31, 95% CI 1.03-1.68).
    Conclusions: This study suggests that the use of zolpidem might increase the risk of subsequent glaucoma. Further confirmatory studies are recommended to clarify this important issue.
    關聯: Journal of Epidemiology 25(1), pp.15-19
    DOI: 10.2188/jea.JE20140051
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