English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 57517/91034 (63%)
造访人次 : 13457021      在线人数 : 330
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/104681


    题名: Growth-suppressive effect of berberine on endometrial carcinoma cells: Role of mitochondrial and PI3K/Akt pathway
    作者: Han-Peng Kuo;Yi-Jen Lee;Chih-Yu Hsu;Shou-Lun Lee;Shih-Chung Hsu;Tzu-Chao Chuange;Jah-Yao Liuf;Chao-Lin Kuo;Chi-Tang Ho;Ming-Ching Kao
    关键词: Berberine;Endometrial cancer;Dietary supplement;Functional food ingredient;PI3K/Akt pathway
    日期: 2015-08
    上传时间: 2016-01-06 11:07:02 (UTC+8)
    出版者: Elsevier BV
    摘要: Berberine is an isoquinoline alkaloid and a popular dietary supplement in the US market for lowering blood glucose and managing a healthy lipid profile. The anti-tumour activity of berberine is also known. Endometrial cancer is a gynecological malignancy tumour. Our study demonstrated for the first time that berberine could be used to inhibit endometrial carcinoma cell proliferation in vitro and unveiled the relevant mechanisms. By flow cytometry, we found that berberine affected cell cycle distribution in endometrial cancer cells. Additionally, berberine could induce cell apoptosis through activation of the mitochondrial/caspase pathway. We further investigated berberine-mediated signal transduction in endometrial cancer cells and found that berberine engaged in the PI3K/Akt pathway, a cell proliferation- and cell cycle progression-related signalling pathway. Our results suggest that berberine could be used as a potential dietary supplement or functional food ingredient to prevent endometrial cancer.
    關聯: Journal of Functional Foods 17, pp.600-609
    DOI: 10.1016/j.jff.2015.06.006
    显示于类别:[化學學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML170检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈