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    題名: Growth-suppressive effect of berberine on endometrial carcinoma cells: Role of mitochondrial and PI3K/Akt pathway
    作者: Han-Peng Kuo;Yi-Jen Lee;Chih-Yu Hsu;Shou-Lun Lee;Shih-Chung Hsu;Tzu-Chao Chuange;Jah-Yao Liuf;Chao-Lin Kuo;Chi-Tang Ho;Ming-Ching Kao
    關鍵詞: Berberine;Endometrial cancer;Dietary supplement;Functional food ingredient;PI3K/Akt pathway
    日期: 2015-08
    上傳時間: 2016-01-06 11:07:02 (UTC+8)
    出版者: Elsevier BV
    摘要: Berberine is an isoquinoline alkaloid and a popular dietary supplement in the US market for lowering blood glucose and managing a healthy lipid profile. The anti-tumour activity of berberine is also known. Endometrial cancer is a gynecological malignancy tumour. Our study demonstrated for the first time that berberine could be used to inhibit endometrial carcinoma cell proliferation in vitro and unveiled the relevant mechanisms. By flow cytometry, we found that berberine affected cell cycle distribution in endometrial cancer cells. Additionally, berberine could induce cell apoptosis through activation of the mitochondrial/caspase pathway. We further investigated berberine-mediated signal transduction in endometrial cancer cells and found that berberine engaged in the PI3K/Akt pathway, a cell proliferation- and cell cycle progression-related signalling pathway. Our results suggest that berberine could be used as a potential dietary supplement or functional food ingredient to prevent endometrial cancer.
    關聯: Journal of Functional Foods 17, pp.600-609
    DOI: 10.1016/j.jff.2015.06.006
    顯示於類別:[化學學系暨研究所] 期刊論文

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