THE EFFECTS OF EXTENSIONAL STRESS ON RED BLOOD CELL HEMOLYSIS

doi:10.4015/S1016237215500428

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Title:	THE EFFECTS OF EXTENSIONAL STRESS ON RED BLOOD CELL HEMOLYSIS
Authors:	Jen-Hong Yen;Sheng-Fu Chen;Ming-Kai Chern;Po-Chien Lu
Keywords:	Hemolysis;Computational;Fluid dynamics;Extensional stress;Short capillary
Date:	2015-09-07
Issue Date:	2016-01-06 11:06:51 (UTC+8)
Publisher:	World Scientific
Abstract:	Arti¯cial prostheses create non-physiologic °ow conditions with stress forces that may induce blood cell damage, particularly hemolysis. Earlier computational °uid dynamics (CFD) prediction models based on a quanti¯ed power model showed signi¯cant discrepancies with actual hemolysis experiments. These models used the premise that shear stresses act as the primary force behind hemolysis. However, additional studies have suggested that extensional stresses play a more substantial role than previously thought and should be taken into account in hemolysis models. We compared extensional and shear stress °ow ¯elds within the contraction of a short capillary with sharp versus tapered entrances. The °ow ¯eld was calculated with CFD to determine stress values, and hemolysis experiments with porcine red blood cells were performed to correlate the e®ects of extensional and shear stress on hemolysis. Our results support extensional stress as the primary mechanical force involved in hemolysis, with a threshold value of 1000 Pa under exposure time less than 0.060 ms.
Relation:	Biomedical Engineering: Applications, Basis and Communications 27(5), pp.1550042(11 pages)
DOI:	10.4015/S1016237215500428
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article [Graduate Institute & Department of Water Resources and Environmental Engineering] Journal Article

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