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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/104671

    Title: A sensitive bithiophene-based biosensor for interferon-gamma characterization and analysis
    Authors: Tsai, P.I.;Lee, S.S.;Chou, S.T.;Jan, C.M.;Chang, Y.T.;Lee, A.S.Y.;Lee, C.K.
    Keywords: Surface plasmon resonance;Ellipsometry;Interferon-gamma;Phase-interrogation;Bithiophene
    Date: 2014-11-28
    Issue Date: 2016-01-06 11:06:44 (UTC+8)
    Abstract: Real-time, label-free monitoring offers a wide range of applications to the biotech field. We developed an integrated bio-sensing platform which adapts a circular polarization interferometry configuration and a phase modulated ellipsometer to improve the performance of biomolecular measurements. An bithiophene-based conductive linker-5′-(mercapto)-[2, 2′-bithiophene]-5-carboxylic acid was developed for detecting antibody–antigen interactions. In this study, the biomarker interferon-gamma (IFN-γ), one of the most important indicators of tuberculosis, was chosen to test and verify the sensitivity of our measurement system. Our experimental results showed that an increase in the concentration of the IFN-γ (64 pM to 1 μM) was usually accompanied by a phase increase. This result is good evidence that our biosensing system can be useful for analyzing biomolecular interactions.
    Relation: Thin Solid Film 571(3), pp.473-477
    DOI: 10.1016/j.tsf.2013.12.037
    Appears in Collections:[化學學系暨研究所] 期刊論文

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