Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice

doi:10.1016/j.jcis.2015.07.044

機構典藏 > College of Sciences > Graduate Institute & Department of Chemistry > Journal Article > Item 987654321/104669

Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/104669

Title:	Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice
Authors:	Kankala, Ranjith Kumar;Kuthati, Yaswanth;Sie, Huei-Wun;Shih, Hung-Yuan;Lue, Sheng-I;Kankala, Shravankumar;Chien-Chung Jeng, Jin-Pei Deng;Weng, Ching-Feng;Liu, Chen-Lun;Lee, Chia-Hung
Keywords:	Layered double hydroxides;Nanoparticles;Oral drug delivery;Sulfasalazine;Eudragit copolymer;Inflammatory
Date:	2015-11-15
Issue Date:	2016-01-06 11:06:41 (UTC+8)
Abstract:	Multiple layers of pH-sensitive enteric copolymers were coated over layered double hydroxide (LDH) nanoparticles for controllable drug release and improved solubility of hydrophobic drugs. The nano-sized LDH carriers significantly improved the accessibility of sulfasalazine molecules that have positively charged frameworks. In addition, the successful encapsulation of negatively charged enteric copolymers was achieved via electrostatic attractions. The multi-layered enteric polymer coating could potentially protect nanoparticle dissolution at gastric pH and accelerate the dissolution velocity, which would improve the drug bioavailability in the colon. Next, biological studies of this formulation indicated a highly protective effect from the scavenging of superoxide free radicals and diethyl maleate (DEM) induced lipid peroxidation, which are major cell signalling pathways for inflammation. The histological view of the liver and kidney sections revealed that the nanoformulation is safe and highly biocompatible. The animal studies conducted via paw inflammation induced by complete Freund’s adjuvant (CFA) revealed that enteric-coated LDH-sulfasalazine nanoparticles provided a sustained release that maintained the sulfasalazine concentrations in a therapeutic window. Therefore, this nanoformulation exhibited preferential efficacy in reducing the CFA-induced inflammation especially at day 4.
Relation:	Journal of Colloid and Interface Science 458, pp.217–228
DOI:	10.1016/j.jcis.2015.07.044
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	218	View/Open
Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice.pdf		2939Kb	Adobe PDF	1	View/Open

Loading...