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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/103480

    Title: Cobalt-Catalyzed Dual Annulation of o-Halobenzaldimine with Alkyne: A Powerful Route toward Bioactive Indenoisoquinolinones
    Authors: 謝仁傑
    Keywords: azametallacycles;cobalt;indenes;isoquinoline;zinc
    Date: 2016-06-22
    Issue Date: 2015-07-28 16:31:42 (UTC+8)
    Publisher: Wiley
    Abstract: A cobalt-catalyzed dual annulation reaction for the synthesis of variously substituted indenoisoquinolinones from 2-bromobenzaldehydes, amines, and methyl 2-(ethynyl)benzoates has been developed. This method could also be applied to the synthesis of an array of highly functionalized bioactive indenoisoquinolinones and their derivatives. A possible mechanism of the cobalt catalysis is proposed, involving imine formation from bromobenzaldehyde and the amine, followed by a series of oxidative addition, alkyne insertion, cyclization reactions, and carbon-carbon double-bond migration. The regioselective alkyne insertion plays an important role for the success of the second annulation.
    Relation: Chemistry 21(26), p.9544–9549
    DOI: 10.1002/chem.201501152
    Appears in Collections:[化學學系暨研究所] 期刊論文

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