Hydride-Induced Anionic Cyclization: An Efficient Method for the Synthesis of 6-H-Phenanthridines via a Transition-Metal-Free Process

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Title:	Hydride-Induced Anionic Cyclization: An Efficient Method for the Synthesis of 6-H-Phenanthridines via a Transition-Metal-Free Process
Authors:	謝仁傑
Date:	2015-03-12
Issue Date:	2015-07-28 16:28:17 (UTC+8)
Publisher:	ACS
Abstract:	A novel procedure for hydride-induced anionic cyclization has been developed. It includes the reduction of a biaryl bromo-nitrile with a nucleophilic aromatic substitution (SNAr). A range of polysubstituted 6-H-phenanthridines were so obtained in moderate to good yield with good substrate tolerance. This method involves a concise transition-metal-free process and was applied to synthesize natural alkaloids.
Relation:	Organic Letters 17(6), p.1613-1616
DOI:	10.1021/acs.orglett.5b00544
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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