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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/102142

    Title: 合成高螢光效率的1, 8-萘醯亞胺衍生物
    Other Titles: Synthesis of highly efficiency fluorescent 1,8-naphthalimide derivatives
    Authors: 劉任偉;Liu, Jen-Wei
    Contributors: 淡江大學化學學系碩士班
    施增廉;Shih, Tzenge-Lien
    Keywords: 1,8-萘醯亞胺;螢光探針;抗腫瘤藥物;螢光分子顯影劑;螢光染料;1,8-Naphthalimide Fluorescent probes;Anticancer agents;Fluorescent cellular imaging agents;Fluorescent dyes
    Date: 2014
    Issue Date: 2015-05-04 09:48:28 (UTC+8)
    Abstract: 1, 8-萘醯亞胺類衍生物的合成被廣泛的應用及探討,因為此類化合物都具有強烈螢光的特點。研究發現,該類化合物結構上萘環的平面性及穩定共軛系統產生良好的光化學穩定性、較大的斯托克斯位移及多重螢光的性質,因此該類化合物可作為螢光偵測器、抗腫瘤藥物、螢光分子顯影劑和螢光染料,近年來,許多科學家致力研究新穎的合成方式來合成1, 8-萘醯亞胺類衍生物,因此我們也設計了兩系列的衍生物,期望未來能近一步研究其應用。
    1, 8 - Naphthalimides derivatives have strong fluorescence characters and their synthesis have been widely studied. They have been commonly used as fluorescent probes, anticancer agents, fluorescent cellular imaging agents and fluorescent dyes. They possess planar scaffold and stable conjugated system to lead to more photochemical stability, large Stokes shift and multiple fluorescence properties.
    Because 1, 8 - Naphthalimides derivatives have various application, therefore we want to explane a facile synthesis of derivatives to expect higher fluorescence efficiency.
    The first part is synthesis of nitrogen 1, 8 - Naphthalimides derivatives. These compounds can be complex with metal ion through lone pairs to lead to chelating structure. The fluorescence properties would be changed that can be used the metal ion probe in the future. Furthermore we can test its structure – activity relationship (SAR) studies as anticancer agents.
    The second part is synthesis of extended 1, 8 - Naphthalimides planarity derivatives. Arylation of azoles is mediated by Pd – Cu system. We can change the resulting adducts from weaker blue - violet fluorescence to stronger conjugated system with yellow-green fluorescence. It can be novel fluorescent labeling agents or fluorescent dyes.
    Low concentrations, these different functional 1, 8 - Naphthalimides derivative to produce intense fluorescence properties. They can be more widely used in various aspects.
    Appears in Collections:[化學學系暨研究所] 學位論文

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