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|Other Titles: ||Catalyst-free synthesis of 1,5-Benzodiazepines by cyclocondensation of β,γ-unsaturated ketones with o-phenylenediamine|
|Authors: ||朱彥睿;Zhu, Yen-Ruei|
|Keywords: ||1,5-苯二氮䓬類;鄰苯二胺;無催化劑;β,γ-不飽和酮;1,5-Benzodiazepine;o-Phenylenediamine;Catalyst-free Synthesis;β,γ-Unsaturated ketone|
|Issue Date: ||2015-05-04 09:48:26 (UTC+8)|
The benzodiazepines have attracted much attentions as pharmacophoric scaffold of heterocycles with a wide range of biological applications. These compounds are served as potentially biological compound with antianxiety, anti-depress, anti-inflammatory, anti-viral, anti-HIVand anti-microbial activities.Many synthetic methods for benzodiazepines have been reported,and mostly with the introduction of catalyst.
We developed a novel catalyst-free method synthetic of 1,5-benzodiazepines which was obtained under sonochemical Barbier-type reaction conditions. A reation mixture of activated magnesium powder, allyl bromide and aldehyde was sonicated to genterate allyl alcohol, followed by treatment of PCC to oxidize the allyl alcohol to allyl ketone.The cyclocondensation reaction of allyl ketone with o-phenylenediamine can produce 1,5-Benzodiazepines.
|Appears in Collections:||[化學學系暨研究所] 學位論文|
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