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https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/102137
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| 題名: | 十九碳五烯乙酯前驅物之全合成 |
| 其他題名: | Total synthesis of (4z,7z,10z,13z,16z)-ethyl nonadeca-4,7,10,13,16-pentaenoate (ENDP) precursor |
| 作者: | 謝宗穎;Hsieh, Tsung-Ying |
| 貢獻者: | 淡江大學化學學系碩士班
李世元 |
| 關鍵詞: | 魚油;碘化銅;DHA;EPA;Fish oil;CuI |
| 日期: | 2014 |
| 上傳時間: | 2015-05-04 09:48:20 (UTC+8) |
| 摘要: | 魚油含有非常多種類的脂肪酸，其中最廣泛為人所知且最有益處即是Omega-3脂肪酸，Omega-3是人體所必需卻不能自體製造的必須脂肪酸，在臨床上Omega-3的生理作用為降低血脂肪和消炎…等，在預防因血液凝集產生的動脈硬化或心肌梗塞更具有明顯效果。
魚油中常見的主要脂肪酸結構如下圖，且依結構中雙鍵的數量可以分成三大類型：飽和、單元不飽和以及多元不飽和脂肪酸。
CH3(CH2)m(CH=CHCH2)n(CH2)oCOOH
當n=0時，此結構稱為飽和脂肪酸，n=1時，為單元不飽和脂肪酸，n=2~6為多元不飽和脂肪酸。目前有許多長碳鏈 (C14-C22) 不飽和脂肪酸，和少量的(C10和C12)單元不飽和脂肪酸陸陸續續從魚油中被確認並鑑定其結構。
本研究的目的是利用全合成方法，設計合成出十九碳五烯乙基酯（EE form）的前驅物，可用來檢測魚油中是否含有此類型Omega-3的多元不飽和脂肪酸分子。
The fatty acids derived from fish oils employ as of three principal types: saturated, monounsaturated, and polyunsaturated fatty acid.
Among those fatty acids in the fish oil, Omega-3, polyunsaturated fatty acid has shown most health benefits. Most current research presents that the anti-inflammatory activities of long-chain Omega-3 fatty acids may transform their biological activities into clinical applications. Omega-3 molecules have been considered as essential fatty acids for the human body, but they can’t be produced by human’s biological metabolism. The sole method to get the Omega-3 is by ingestion pathway.
The aim of the study is to determine the specific structure of the fatty acid in fish oil and health supplements which containing the substance |
| 顯示於類別: | [化學學系暨研究所] 學位論文
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