銅催化腈基插入以及合環反應形成菲啶酮及菲啶衍生物

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Title:	銅催化腈基插入以及合環反應形成菲啶酮及菲啶衍生物
Other Titles:	Copper-catalysed cascade reaction involving addition of nitrile and annulation to form the phenanthridinone and phenanthridine derivatives
Authors:	陳彥甫;Chen, Yan-Fu
Contributors:	淡江大學化學學系碩士班謝仁傑;Hsieh, Jen-Chieh
Keywords:	銅催化;菲啶酮;菲啶;Copper-catalysed;cascade reaction;phenanthridinone;phenanthridine
Date:	2014
Issue Date:	2015-05-04 09:48:02 (UTC+8)
Abstract:	第一部分: 利用銅金屬催化進行碳-氧鍵和碳-氮鍵偶合的串聯反應。這個方法能有效地利用多種不同類型的取代基合成出多取代的菲啶銅，並且得到良好的產率。第二部份: 使用了銅金屬催化合成菲啶骨架類化合物，而利用格林納試劑插入氰基取代還原。在反應中能忍受多樣的取代基及具有雜環的化合物，且在產率上也有著極好的表現。 The 1st Part: copper-catalyzed cascade reaction of C–O and C–N bond coupling. This method efficiently provides poly-substituted (NH)- phenanthridinones in moderate to good yields with tolerance of a wide variety of substrates. The 2st Part: copper-catalyzed annulation reaction involving addition of the Grignard reagent to nitrile and C–N bond coupling. This method efficiently provides poly-substituted phenanthridines in moderate to good yields with tolerance of a very wide variety of substrates.
Appears in Collections:	[Graduate Institute & Department of Chemistry] Thesis

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