For junior high school students, when they exposure to the chemical learning, most students find it difficult to remember the names of chemistry elements and their attributes. This study developed a set of embedded memory strategy digital game for students which followed related education theory and let the students naturally remember the properties of chemistry elements in the game. To explore the effect of memory strategy embedded in the digital game-based learning (DGBL), this study selected 135 students and divided them by digital game and traditional blackboard learning groups. The results reveal that DGBL not only can be used to reduce the learning difficulties but enhance student learning outcomes. Girls in DGBL have shown improving their learning outcomes more significantly. This study suggests applying memory strategies into the digital learning materials can achieve learning goals. For further application, this technology may be used to different platforms to enhance related learning.